Question:
What is the first question in the Bible?

Answer:
“Now the serpent was more subtil than any beast of the field which the LORD God had made. And he said unto the woman, Yea, hath God said, Ye shall not eat of every tree of the garden?” (Genesis 3:1).

Satan asked this question of Eve, but Satan was really questioning God. When God says something it is true. Because in Genesis 2:16 and 17: “The LORD God commanded the man, saying, Of every tree of the garden thou mayest freely eat: but of the tree of the knowledge of good and evil, thou shalt not eat of it: for in the day that thou eatest thereof thou shalt surely die.”
The result of the question is in verses 2-9: The woman sinned. Satan lied to her, so she ate of the tree. Because our first parents sinned we are born sinners, born into a sinful race (Romans 5:12, Psalm 51:5). Adam turned away from God, and all his descendants did also, for “All we like sheep have gone astray; we have turned everyone to his own way; and the LORD hath laid on him the iniquity of us all” (Isaiah 53:6).
We all need to have our sins taken away so we can go to heaven. We need to be saved! Christ bore the wrath of God against our sins on the cross of Calvary and therefore “He that believeth on the Son hath everlasting life: and he that believeth not the Son shall not see life; but the wrath of God abideth on him” (John 3:36).